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外文期刊>european journal of neuroscience
>Potent Analgesia Induced in Rats by Combined Action at PCP and Polyamine Recognition Sites of the NMDA Receptor Complex
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Potent Analgesia Induced in Rats by Combined Action at PCP and Polyamine Recognition Sites of the NMDA Receptor Complex
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机译：Potent Analgesia Induced in Rats by Combined Action at PCP and Polyamine Recognition Sites of the NMDA Receptor Complex
AbstractThe present study was performed to examine the analgesic effects of the intrathecal administration of agents acting at various sites in theN‐methyl‐d‐aspartic acid (NMDA) receptor complex on the nociceptive responses to s.c. formalin injection in rats. Both the competitive NMDA receptor antagonist 2‐amino‐5‐phosphonovaleric acid (APV) and the non‐competitive NMDA antagonist dizocilpine maleate (MK‐801) produced dose‐dependent analgesic effects in the late, but not the early, phase of the formalin test. The polyamine antagonist ifenprodil, and the strychnine‐insensitive glycine antagonists DCQX and 7‐chlorokynurenic acid, failed to produce any analgesic effects in either the early or the late phase of the formalin test. The analgesic effects of APV were enhanced slightly by combined administration with a non‐analgesic dose of glycine, and the analgesic effects of MK‐801 were dramatically potentiated by combined adminstration of a non‐analgesic dose of the polyamine spermine. The results indicate that much more potent analgesia can be produced in the formalin test by a combination of open channel blockers (such as MK‐801) withagonistsacting at the polyamine site, than by a single treatment withantagoniststo either glycine allosteric or polyamine sites wit
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