...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>journal of cellular physiology >Localization of p35 (annexin I, lipocortin I) in normal adult rat kidney and during recovery from ischemia
【24h】

Localization of p35 (annexin I, lipocortin I) in normal adult rat kidney and during recovery from ischemia

机译：Localization of p35 (annexin I, lipocortin I) in normal adult rat kidney and during recovery from ischemia

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

AbstractThe 35‐kDa protein (p35, lipocortin I, annexin I), originally discovered as a Ca++‐dependent substrate for the EGF receptor tyrosine kinase, binds Ca++and phospholipids, is developmentally regulated in embryos and has restricted expression in adults. Immunohistochemistry of normal rat kidney shows that p35 is enriched in epithelia of Bowman's capsule, the macula densa, and medullary/papillary collecting ducts, suggesting that p35 is related to specialized renal functions. Light staining is observed in the thick ascending limb; elsewhere, immunoreactivity is nil. Since renal recovery from ischemia involves both hyperplasia and hypertrophy and reportedly is accelerated by EGF, we examined p35 distribution during this process. After 48 hours of recovery, both the distribution and amount of renal p35 are altered. Immunoblots show p35 levels increased at least threefold in whole‐kidney homogenates. The expression of p35 is still highly restricted in recovering kidneys; however, the thick ascending limb now stains heavily. This is the first documentation of alterations in annexin levels during a pathophysiologic response. However, our attempts to discern effects of exogenous EGF on the recovery from ischemia were negative for both mitotic index and renal function assays. © 1992 Wiley‐L

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号