...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>journal of applied toxicology >Acute toxicity and mutagenicity of the copper complex of pyruvaldehyde‐bis (N‐4‐methylthiosemicarbazone), Cu‐PTSM
【24h】

Acute toxicity and mutagenicity of the copper complex of pyruvaldehyde‐bis (N‐4‐methylthiosemicarbazone), Cu‐PTSM

机译：Acute toxicity and mutagenicity of the copper complex of pyruvaldehyde‐bis (N‐4‐methylthiosemicarbazone), Cu‐PTSM

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

AbstractCu‐PTSM is a potential imaging agent for the heart and brain when labeled with either64Cu or62Cu. Unlabeled Cu‐PTSM was evaluated for its acute toxicity and mutagenicity. Cu‐PTSM had an i.v. LD50of 26 mg kg−1in the rat and 2 mg kg−1in the rabbit. At necropsy, rats exhibited severely hemorrhagic lungs, histological findings of acute pulmonary congestion, hemorrhage and edema, and mild congestion in kidney, liver and brain. The rabbit displayed marked polymorphonuclear infiltration in alveoli, peribronchial and periarterial areas with marked macrophage hyperplasia, congestion and mild hemorrhage into alveolar spaces. No effects were found in kidney, liver, testes or brain. Administration of 2.16 μg kg−1day−1for 5 days per week for 2 weeks resulted in no changes in histopathology, hematology or clinical chemistry parameters. This daily dose is at least 300 times the diagnostic dose intended for use in man. Cu‐PTSM was not mutagenic when tested in the absence ofS9 supernatant, but elicited a weakly mutagenic response in the presence ofS9. Since acute effects in the lung occur at doses approaching 300000 times the diagnostic dose, it is highly unlikely that the clinical use of Cu‐PTSM would result in any acu

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号