Twelve patients with metastatic non-seminomatous germ-cell tumours who relapsed after 3–9 courses (median 7) ofcis-platin containing combination chemotherapy, were treated with moderately high-dose methotrexate (1 g m−2) and folinic acid rescue. There was one partial response and the remaining eleven patients showed progression of disease. The patient that responded was one of two patients treated at the time of first rela
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