NA;Tension measurements were made on rabbit basilar artery segments to test the direct effect of thiopental on serotonin lpar;5HTrpar;hyphen; and norepinephrine lpar;NErpar;hyphen;induced contraction. At concentrations of 3 times; 10hyphen;5Mor greater, thiopental caused relaxation of NEhyphen;induced tension. Thiopental doses greater than 3 times; 10hyphen;4Mhad a similar relaxing effect on 5HThyphen;induced contraction. However, thiopental doses below 3 times; 10hyphen;4Mdemonstrated an unexpected dosehyphen;dependent potentiation of the 5HThyphen;induced contraction. lpar;Neurosurgery17colon;433hyphen;435, 1985rpar;
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