Concomitant association of giant cell arteritis and malignancy: a multicenter retrospective case-control study

Deshayes S.; Liozon E.; Chanson N.Sacre K.Moulinet T.Blanchard-Delaunay C.Espitia O.Groh M.Versini M.Le Gallou T.Kahn J-EGrobost VHumbert S.Samson M.Cottet R. MourotMazodier K.Dartevel A.Campagne J.Dumont A.Bienvenu B.Lambert M.Daumas A.Saadoun D.Aouba A.de Boysson H.

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Concomitant association of giant cell arteritis and malignancy: a multicenter retrospective case-control study

机译：Concomitant association of giant cell arteritis and malignancy: a multicenter retrospective case-control study

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IntroductionSome studies suggest that there is an increased risk of malignancies in giant cell arteritis (GCA). We aimed to describe the clinical characteristics and outcomes of GCA patients with concomitant malignancy and compare them to a GCA control group.MethodPatients with a diagnosis of GCA and malignancy and with a maximal delay of 12months between both diagnoses were retrospectively included in this study and compared to a control group of age-matched (3:1) patients from a multicenter cohort of GCA patients.ResultsForty-nine observations were collected (median age 76years). Malignancies comprised 33 (67) solid neoplasms and 16 (33) clonal hematologic disorders. No over-representation of a particular type of malignancy was observed. Diagnosis of GCA and malignancy was synchronous in 7 (14) patients, while malignancy succeeded GCA in 29 (59) patients. Malignancy was fortuitously diagnosed based on abnormalities observed in laboratory tests in 26 patients, based on imaging in 14 patients, and based on symptoms or clinical examination in the nine remaining patients. Two patients had a concomitant relapse of both conditions. When compared to the control group, patients with concomitant GCA and malignancy were more frequently male (p<0.001), with an altered general state (p<0.001), and polymyalgia rheumatica (p<0.01).ConclusionsThis study does not indicate an over-representation of any particular type of malignancy in GCA patients. Initial follow-up dictated by vasculitis may have led to an early identification of malignancy. Nevertheless, GCA male patients with an altered general state and polymyalgia rheumatica might more frequently show concomitant malignancies.

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《Clinical rheumatology》 |2019年第5期|1243-1249|共7页
作者
Deshayes S.; Liozon E.; Chanson N.Sacre K.Moulinet T.Blanchard-Delaunay C.Espitia O.Groh M.Versini M.Le Gallou T.Kahn J-EGrobost VHumbert S.Samson M.Cottet R. MourotMazodier K.Dartevel A.Campagne J.Dumont A.Bienvenu B.Lambert M.Daumas A.Saadoun D.Aouba A.de Boysson H.;
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CHU Limoges, Dept Internal Med, Limoges, France;

Hop Bichat Claude Bernard, Dept Internal Med, Paris, France;

CHU Estaing, Dept Internal Med, Clermont Ferrand, FranceNormandie Univ, UNICAEN, CHU Caen Normandie, Dept Internal Med & Clin Immunol, Ave Cote Nacre, FCHU Besancon, Dept Internal Med, Besancon, FranceCHU Dijon, Dept Internal Med & Clin Immunol, Dijon, FranceHop La Pitie Salpetriere, Dept Internal Med, Paris, FranceHop Prives Metz, Dept Internal Med, Metz, FranceCHU Nantes, Dept Internal Med, Nantes, FranceCtr Hosp Georges Renon, Dept Internal Med, Niort, FranceHop Civil, Dept Internal Med, Strasbourg, FranceCHU Marseille, Dept Geriatr & Internal Med, Marseille, FranceCHU Grenoble, Dept Internal Med, Grenoble, FranceHop Instruct Armees, Dept Infect & Syst Dis, Metz, FranceHop St Joseph, Dept Internal Med, Marseille, FranceCHU Lille, Dept Internal Med, Lille, FranceHop Foch, Natl Referral Ctr Hypereosinophil Syndromes CEREO, Dept Internal Med, Suresnes, FranceInst Arnault Tzanck, St Laurent Du Var, FranceCHU Rennes, Dept Internal Med, Rennes, FranceHop Ambroise Pare, Dept Internal Med, Boulogne, Billancourt, FranceHop Conception, Dept Internal Med, Marseille, France;

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正文语种英语
中图分类内科学;
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Giant cell arteritis; Hematologic neoplasms; Malignancy; Neoplasms;

Concomitant association of giant cell arteritis and malignancy: a multicenter retrospective case-control study

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