AbstractMicrocalorimetry is introduced briefly and shown to permit the development of biologically based Structure Activity Relationships (SARs). These data can be related to the more conventionally used parameter, the partition coefficient. Further, calorimetric studies are shown to allow comparison of the partitioning properties of biological cells with solvents that are normally used in drug partitioning studies. The results indicate that more consideration should be given to partitioning into particulate, e.g. micellar and liposomal, solvent systems. The use of the Taylor‐Aris dispersion broadening method is briefly introduced theoretically, and its practical exploitation is discussed.These two techniques, microcalorimetry and the Taylor‐Aris method are shown to allow new insights into partitioning systems and their application to biological S
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