Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes.

Ventre I; Goodman AL; Vallet Gely IVasseur PSoscia CMolin SBleves SLazdunski ALory SFilloux A

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Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes.

机译：Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes.

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The opportunistic pathogen Pseudomonas aeruginosa is responsible for a wide range of acute and chronic infections. The transition to chronic infections is accompanied by physiological changes in the bacteria favoring formation of biofilm communities. Here we report the identification of LadS, a hybrid sensor kinase that controls the reciprocal expression of genes for type III secretion and biofilm-promoting polysaccharides. Domain organization of LadS and the range of LadS-controlled genes suggest that it counteracts the activities of another sensor kinase, RetS. These two pathways converge by controlling the transcription of a small regulatory RNA, RsmZ. This work identifies a previously undescribed signal transduction network in which the activities of signal-receiving sensor kinases LadS, RetS, and GacS regulate expression of virulence genes associated with acute or chronic infection by transcriptional and posttranscriptional mechanisms.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2006年第1期|171-176|共6页
作者
Ventre I; Goodman AL; Vallet Gely IVasseur PSoscia CMolin SBleves SLazdunski ALory SFilloux A;
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作者单位

Laboratoire d'Ingenierie des Systemes Macromoleculaires, Centre National de la Recherche Scientifique, Institut de Biologie Structurale et Microbiologie, Unite Propre de Recherche 9027, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类基础医学;
关键词
virulent characteristics; regulatory; Chronic; Sensors; RNA;

Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes.

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