Enantioseparation of Cinacalcet, and its Two Related Compounds by HPLC with Self-Made Chiral Stationary Phases and Chiral Mobile Phase Additives

Yang Canyu; Li Ji; Yao YanyunQing ChenShen Baochun

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Enantioseparation of Cinacalcet, and its Two Related Compounds by HPLC with Self-Made Chiral Stationary Phases and Chiral Mobile Phase Additives

机译：Enantioseparation of Cinacalcet, and its Two Related Compounds by HPLC with Self-Made Chiral Stationary Phases and Chiral Mobile Phase Additives

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Background: Cinacalcet is one of the second-generation calcimimetics which consists of a chiral center. The pharmacological effect of R-cinacalcet is 1000 times greater than that of the Scinacalcet. As mentioned in many literatures, 1-(1-naphthyl)ethylamine is used as the starting material for the synthesis of cinacalcet. The absolute structure of cinacalcet is influenced by the starting materials.

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来源
《Current pharmaceutical analysis.》 |2019年第2期|200-209|共10页
作者
Yang Canyu; Li Ji; Yao YanyunQing ChenShen Baochun;
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作者单位

Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China;

Dali Nursing Vocat Coll, Dali 671000, Yunnan, Peoples R China;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Enantioseparation; cinacalcet; 1-(1-naphthyl) ethylamine; N-(1-(naphthalen-1-yl) ethyl)-3-(3-(trifluoromethyl) phenyl) propanamide; chiral mobile phase additive; chiral stationary phase;

Enantioseparation of Cinacalcet, and its Two Related Compounds by HPLC with Self-Made Chiral Stationary Phases and Chiral Mobile Phase Additives

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