In a double-blind crossover study the remineralizing effects of the combinations: placebo toothpaste, placebo gel; amine fluoride toothpaste, placebo gel; amine fluoride toothpaste, 0.25 F––/sup> amine fluoride gel and amine fluoride toothpaste, 0.4 F––/sup> amine fluoride gel were investigated in vivo. Artificially demineralized flattened enamel slabs were placed in the buccal flanges of partial dentures. It was found during the 3-week experimental periods that there was a significantly higher increase in remineralization in the 2 fluoride gel groups. This occurred in both the surface layer and subsurface lesion and resulted in a significant decrease in lesion depth and increase in hardness. It is suggested that the weekly use of these gels should be considered in patients with early enamel lesions if they are formed during, or fail to remineralize under, a normal preventive
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