Serum prohepcidin and interleukin-6 in chloramphenicol challenged liver of wistar rat models

Idemili N.G.; Innih S.; Osifo J.E.Osubor C.C.

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Serum prohepcidin and interleukin-6 in chloramphenicol challenged liver of wistar rat models

机译：Serum prohepcidin and interleukin-6 in chloramphenicol challenged liver of wistar rat models

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© CMS UNIBEN JMBR.The role of the disturbances of hepcidin metabolism, the master regulator of iron homeostasis synthesized in the liver, has been raised In cases of impaired liver function. The aims of this study were to evaluate the serum levels of prohopcidin, serum iron, interleukin-6, liver enzymes: aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) and total biirubin, on chloramphenicol-administered Wistar rat models, and also investigate the ameliorative property, if any, of Telfiiiria occiderdulis on chloramphenicol-induced hepatocyte damage. The hepatocytes of 120 male Wistar rate (130-150g) were challenged in clinical conditions of chloramphenicol administration. Prohepcidin and interlaukin-6 were measured by an enzyme linked immunosorbent assay (ELISA) technique, and AST, ALT, ALP and total bilirubin were measured spectrophotometrlcally. 60 rats served as controls, while 60rQts wane test animals. The control sub groups were given T fairta occldentolis leaf extract (50 mg/ml) and ferric hydrmdde (50 mg/5ml) respectively with rat chow, for 21 days, while the test groups were administered Chloram henicol (86mg/kg body weight) for 21 days, with normal feeding and treated as control sub-groups.A significant decrease (p< 0.05) in prohepcidin and ILr6, was observed in chloramphenlcol administered rat models, w e serum AST, ALT, and ALP activities were elevated (p< 0.05) in the rat models. Administration of Tclfairia accidentu to the rat models greatly improved liver function and enhanced humoral immunity of the test animals. In conclusion, serum prohepcidin level was decreased in chloramphenicol-induced liver impairment and Thlfriria occidentalis had restorative and immune boosting properties.

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《journal of medicine and biomedical research》 |2014年第1期|77-85|共页
作者
Idemili N.G.; Innih S.; Osifo J.E.Osubor C.C.;
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作者单位

Dapartmant of Biochemistry, University of Benin;

Department of Chemical Pathology, University of Benin Teaching Hospital;

Department of Anatomy, University of Benin;

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正文语种英语
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Chloramphenicol; Iiver emzymes; Interleukin-6; Iron; Prohopcidin; Telfiiiria occiderdulis;

Serum prohepcidin and interleukin-6 in chloramphenicol challenged liver of wistar rat models

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