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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Cardioprotective effects of (E)-4-hydroxy-N '-(1-(3-oxo-3H-benzofchromen-2-yl)ethylidene)benzohydrazide: a newly synthesized coumarin hydrazone against isoproterenol-induced myocardial infarction in a rat model
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Cardioprotective effects of (E)-4-hydroxy-N '-(1-(3-oxo-3H-benzofchromen-2-yl)ethylidene)benzohydrazide: a newly synthesized coumarin hydrazone against isoproterenol-induced myocardial infarction in a rat model

机译：（E）-4-羟基-N'-（1-（3-氧代-3H-苯并f苯并吡喃-2-基）亚乙基）苯甲酰肼的心脏保护作用：一种新合成的香豆素腙在大鼠模型中对抗异丙肾上腺素诱导的心肌梗死

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The current study was carried out to evaluate the effect of pretreatment and co-treatment with a newly synthesized coumarin hydrazone, (E)-4-hydroxy-N'-(1-(3-oxo-3H-benzofchromen-2-yl)ethylidene)benzohydrazide (hereinafter EK6), against isoproterenol-induced myocardial infarction in rats. Changes in biochemistry, cardiac biomarkers, electrocardiography, and histopathology after treatment with EK6 or acenocoumarol (Sintrom) were studied. Animals were randomly divided into 4 groups: vehicle control (C), isoproterenol + Sintrom (ISO + Sin), isoproterenol + EK6 (ISO + EK6), and isoproterenol (ISO). Myocardial infarction was induced by subcutaneous ISO administration at a dose of 85 mg.kg(-1).day(-1) with a drug-free interval of 24 h on days 6 and 7. Treatment with ISO led to significant elevation (p < 0.05) in serum levels of cardiac injury biomarkers, namely cardiac troponin-T, lactate dehydrogenase, creatine kinase-MB, alanine aminotransferase, and aspartate aminotransferase compared with levels in the vehicle control. A change in the lipid profile was also observed as a significant increase in total cholesterol and triglycerides. Furthermore, ISO caused significant alterations in the electrocardiogram pattern, including significant ST-segment elevation, significant decreased R wave amplitude, and significant increase in heart rate (16) as well as marked changes in the histopathology of the heart tissue. Pretreatment and co-treatment with newly synthesized coumarin hydrazone restored all ISO-induced biochemical, lipid, cardiac, and histopathological changes in rats with myocardial infarction.
机译：本研究旨在评估新合成的香豆素腙（E）-4-羟基-N'-（1-（3-氧代-3H-苯并[f]苯并吡喃-2-基）亚乙基）苯甲酰肼（以下简称EK6）对异丙肾上腺素诱导的大鼠心肌梗的效果。研究了 EK6 或醋硝香豆素 （Sintrom） 治疗后生物化学、心脏生物标志物、心电图和组织病理学的变化。动物随机分为 4 组：载体对照组 （C）、异丙肾上腺素 + Sintrom （ISO + Sin）、异丙肾上腺素 + EK6 （ISO + EK6） 和异丙肾上腺素 （ISO）。第 6 天和第 7 天的无药间隔为 24 小时，皮下注射 ISO 以 85 mg.kg（-1）.day（-1） 的剂量诱导心肌梗死。与载体对照组相比，ISO 治疗导致心脏损伤生物标志物（即心肌肌钙蛋白-T、乳酸脱氢酶、肌酸激酶-MB、丙氨酸氨基转移酶和天冬氨酸氨基转移酶）的血清水平显着升高 （p < 0.05）。还观察到脂质谱的变化，即总胆固醇和甘油三酯的显着增加。此外，ISO 导致心电图模式发生显着改变，包括 ST 段显着升高、R 波振幅显着降低、心率显着增加 （16%） 以及心脏组织病理学的显着变化。预处理和与新合成的香豆素腙的共同处理恢复了心肌梗死大鼠的所有ISO诱导的生化、脂质、心脏和组织病理学变化。

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