SummaryImmunological investigations have been carried out on a haemophiliac patient who had developed severe anaphylaxis to bovine factor VIII administration. Results have shown that the development of anaphylaxis in this patient was associated with a sudden increase in total and specific IgG4 antibodies. The significance of this observation is discussed in relation to current evidence suggesting the involvement of IgG4 antibodies in some anaphylactic conditions.
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