Summary.NK cells from young normal mice are cytolyticin vitrofor a virus‐induced tumour cell line, YAC‐1. Cytotoxicity is inhibited by the addition of unlabelled homologous YAC‐1 cells and by regenerating bone marrow cells from the spleens of lethally irradiated, bone‐marrow‐grafted mice. Quiescent marrow from syngeneic and allogeneic mice produces little or no competition. This suggests that NK cells recognize, and may regulate, marrow progeni
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