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>Induction of Bcl‐2 gene expression by intercellular information from hemopoietic supportive stromal cells to DA‐1 cells
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Induction of Bcl‐2 gene expression by intercellular information from hemopoietic supportive stromal cells to DA‐1 cells
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机译：Induction of Bcl‐2 gene expression by intercellular information from hemopoietic supportive stromal cells to DA‐1 cells
AbstractWhen Interleukin‐3 (IL‐3) dependent DA‐1 cells were cultured on hemopoietic supportive stromal cells (MS‐5), DA‐1 cells survived and proliferated in the absence of detectable IL‐3. Although IL‐3 was not produced by the MS‐5 cells, their production of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) was increased when they were co‐cultured with DA‐1 cells. This suggests that DA‐1 cells transmit signals to stromal cells that enhance growth factor(s) production. Expression of bcl‐2 by DA‐1 cells was induced when they were co‐cultured with MS‐5 cells, suggesting that DA‐1 cells express bcl‐2 strongly in response to a signal produced by MS‐5 cells. These data indicate the existence of a two‐way interaction between DA‐1 cells and hemopoietic sup
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