Elevated glycolytic metabolism is essential for CD8+ T cell antitumor function, but cell-intrinsic factors modulating this process remain elusive. In this issue, Hu et al. (2019) show that the lipid kinase acylgiycerol kinase (AGK) promotes the glycolytic and functional fitness of CD8+ T cells by inactivating PTEN and boosting mTOR activity, thereby promoting antitumor activity.
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