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>Hyperthermic EffectsIn vitroon the Peripheral Lymphocytes Isolated from Three Cases of Malignant Lymphoma/Leukemia
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Hyperthermic EffectsIn vitroon the Peripheral Lymphocytes Isolated from Three Cases of Malignant Lymphoma/Leukemia
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机译：Hyperthermic EffectsIn vitroon the Peripheral Lymphocytes Isolated from Three Cases of Malignant Lymphoma/Leukemia
AbstractWe have carried outin vitrostudies of hyperthermic effects on the viability, blastogenesis, and ultrastructural changes of atypical lymphocytes isolated from the peripheral blood of three patients with malignant lymphoma/leukemia. One was lymphocytic lymphoma/leukemia (T‐cell origin), and the others were adult T‐cell lymphoma/leukemia (both acute and smoldering type). In the cases of adult T‐cell lymphoma/leukemia, the peripheral lymphocytes were found to be more sensitive to hyperthermia than those of non‐ATL patients in terms of trypan‐blue exclusion ability and blastogenesis ability with concanavalin A challenge. When heated under sublethal conditions, lymphocytes of both ATL and non‐ATL patients exhibited the following characteristics: production of multilayered nuclear membranes, increase in vesicles (lysosomes), swelling of mitochondria, and cytoplasmic va
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