Disposition decomposition analysis is used as a framework to derive a parameter for the description of drug distribution kinetics. This parameter, denotedtd, is a measure of the mean time for equilibration of distribution in the absence of metabolic drug elimination. The derivation requires only the assumption that distribution is linear, and is generally valid as long as any nonlinearity is due to central nonlinear elimination. The mean time for equilibration of distribution,td, is evaluated in terms of the moments of the distribution function,h(t), derived by disposition decomposition analysis. Estimates oftdfor several drugs are presented.
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