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外文期刊>Oral microbiology and immunology
>Effects of extracts fromBacteroides gingivalis, Bacteroides intermedius, andBacteroides asaccharolyticuson the growth of fibroblast lines obtained from healthy and inflamed human gingiva
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Effects of extracts fromBacteroides gingivalis, Bacteroides intermedius, andBacteroides asaccharolyticuson the growth of fibroblast lines obtained from healthy and inflamed human gingiva
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机译：Effects of extracts fromBacteroides gingivalis, Bacteroides intermedius, andBacteroides asaccharolyticuson the growth of fibroblast lines obtained from healthy and inflamed human gingiva
The effect of sonicates fromBacteroides gingivalis, Bacteroides intermedius, andBacteroides asaccharolyticuson the uptake of (3H)‐thymidine by different gingival fibroblast cell lines was studied. Extracts fromB. intermediusstimulated thymidine uptake by as much as 150 over that of controls. This effect varied according to both the fibroblast line and the concentration of the bacterial extract.B. asaccharolyticusextracts inhibited the thymidine uptake of all fibroblast cell lines at high concentrations, but in low doses the thymidine uptake was stimulated in some fibroblast lines by up to 200.B. gingivalisextract caused a strong, dose‐dependent inhibition of thymidine uptake in all of the fibroblast lines tested. Low concentrations ofB. gingivalisextract (10 μg protein/ml) inhibited DNA‐synthesis by 12‐60, and high concentrations (100 μg protein/ml) by 70‐90. The results suggest that the response of periodontal fibroblasts to oralBacteroidesvaries considerably depending on theBacteroidesspecies, as well as on the individual characteristics of the cell lines b
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