Rare Sugar Syrup Containing D-Allulose but Not High-Fructose Corn Syrup Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic Glucokinase Translocation in Wistar Rats

Shintani Tomoya; Yamada Takako; Hayashi NorikoIida TetsuoNagata YasuoOzaki NobuakiToyoda Yukiyasu

首页> 外文期刊>Journal of Agricultural and Food Chemistry >Rare Sugar Syrup Containing D-Allulose but Not High-Fructose Corn Syrup Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic Glucokinase Translocation in Wistar Rats

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Rare Sugar Syrup Containing D-Allulose but Not High-Fructose Corn Syrup Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic Glucokinase Translocation in Wistar Rats

机译：Rare Sugar Syrup Containing D-Allulose but Not High-Fructose Corn Syrup Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic Glucokinase Translocation in Wistar Rats

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Ingestion of high-fructose corn syrup (HFCS) is associated with the risk of both diabetes and obesity. Rare sugar syrup (RSS) has been developed by alkaline isomerization of HFCS and has anti-obesity and anti-diabetic effects. However, the influence of RSS on glucose metabolism has not been explored. We investigated whether long-term administration of RSS maintains glucose tolerance and whether the underlying mechanism involves hepatic glucokinase translocation. Wistar rats were administered water, RSS, or HFCS in drinking water for 10 weeks and then evaluated for glucose tolerance, insulin tolerance, liver glycogen content, and subcellular distribution of liver glucokinase. RSS significantly suppressed body weight gain and abdominal fat mass (p < 0.05). The glucose tolerance test revealed significantly higher blood glucose levels in the HFCS group compared to the water group, whereas the RSS group had significantly lower blood glucose levels from 90 to 180 min (p < 0.05). At 30, 60, and 90 min, the levels of insulin in the RSS group were significantly lower than those in the water group (p < 0.05). The amount of hepatic glycogen was more than 3 times higher in the RSS group than that in the other groups. After glucose loading, the nuclear export of glucokinase was significantly increased in the RSS group compared to the water group. These results imply that RSS maintains glucose tolerance and insulin sensitivity, at least partly, by enhancing nuclear export of hepatic glucokinase.

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《Journal of Agricultural and Food Chemistry》 |2017年第13期|2888-2894|共7页
作者
Shintani Tomoya; Yamada Takako; Hayashi NorikoIida TetsuoNagata YasuoOzaki NobuakiToyoda Yukiyasu;
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作者单位

Matsutani Chem Ind Co, Res & Dev, 5-3 Kita Itami, Itami, Hyogo 6648508, Japan;

Nagasaki Univ, Univ & Govt Cooperat, Ctr Ind, 1-14 Bunkyo Machi, Nagasaki 8529521, Japan;

Japanese Red Cross Nagoya Daiichi Hosp, Nakamuraku Ku, 3-35 Michishita, Nagoya, Aichi 4538511, JapanMeijo Univ, Fac Pharm, Dept Pathobiochem, Tempaku Ku, 150 Yagotoyama, Nagoya, Aichi 4688503, Japan;

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原文格式 PDF
正文语种英语
中图分类营养卫生、食品卫生;农业科学;
关键词
D-allulose; rare sugar; D-psicose; insulin sensitivity; glucokinase;

Rare Sugar Syrup Containing D-Allulose but Not High-Fructose Corn Syrup Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic Glucokinase Translocation in Wistar Rats

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