The differential environmental fates and toxicities of the various hexachlorocyclohexane (HCH) isomers including lindane and isomers in the technical mixture will be the focus of this review. HCHs are one of the most widely used and most readilydetected organochlorine pesticides in environmental samples. The relatively high volatility of HCH has led to global transport, even into formerly pristine locations such as the Arctic. Certain HCHs cause central nervous system, reproductive, andendocrine damage. Becauseγ-HCH is rapidly metabolized, theβ-HCH isomer is consistently found in higher concentrations in human fat, blood, and breast milk. In contrast, α- andγ-HCH are the most prevalent isomers in soil, water, and air samples. Theratio of theα- toγ-isomers can be used to track global transport of HCHs. A new area of HCH research focuses on the selective degradation of the twoα-HCH enantiomers in various environmental matrices. These HCH issues and recommendations for future HCH research are presented in this review.
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