Abstract: This review summarizes present knowledge on porcine plateletsin vitroand recent studies onin vivoactivation of platelets in the pig. There are certain differences compared to human platelets: Platelet aggregation and secretion cannot be achieved by epinephrine, and the arachidonate pathway seems poorly developed in porcine platelets. Genetic models for von Willebrand disease (vWD) and storage pool deficiency (SPD) have been developed in the pig. Several models for the study ofin vivoplatelet deposition and early thrombus formation have been developed. Platelet radio‐labeling techniques (with111In) have been used extensively. We conclude that the pig seems to be a good choice for the investigation ofin vivoplatelet activation and deposition based on present knowledge of porcine platelets and on already established animal mod
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