Nicotinic acid is effective in all forms in hyperlipoproteinemia. Its primary mode of action is to inhibit lipolysis in adipose tissue. Consequently, a reduction in plasma triglyceride, low-density lipoprotein and very-low-density lipoprotein cholesterol and lipoprotein (a) levels as well as a rise in high-density lipoprotein cholesterol are observed. Derivatives, for example acipimox, are free of the major side effects of nicotinic acid, but are apparently less powerful.
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