AbstractThe concentration of neutrophils and megakaryocytes was determined in the marrow of anemic mice of genotypeW/Wvand their normal (+/+) litter mates. In all groups studied, the humerus ofW/Wvmice contained significantly less neutrophils and megakaryocytes than did normal animals. Blood neutrophil concentration was less in all groups ofW/Wvmice but in only one group which was the youngest group studied, did this value differ significantly from normal.The blood and marrow neutrophil response to endotoxin was similar inW/Wvand “+/+” animals. This suggests that the neutrophilic system ofW/Wvmice responds to this stimulus in a relatively normal manner, much as their erythroid system responds to hypoxia, and androg
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