AbstractThe purpose of this study was to investigate the homotypical variation in morphologic and anisotropic properties of trabecular bone from paired canine distal femurs. A microcomputed tomography system was used to produce three‐dimensional digital reconstructions of the trabecular bone structures. The results showed that the mean bilateral differences in all bone morphology variables were<5. Differences in measures of degree of anisotropy were also<5 between matched sites from left and right sides. In general, the bilateral difference in angle of orientation was<15. These data are valuable for calculating the appropriate sample size to use in experiments using the contralateral canine femur as a control. The results and general approach of the study may have significance for the future use of other contralateral trabecular bone sites as control
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