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>Immunofluorescent study of heterogeneity in smooth muscle cells of human fetal vessels using antibodies to myosin, desmin, and vimentin
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Immunofluorescent study of heterogeneity in smooth muscle cells of human fetal vessels using antibodies to myosin, desmin, and vimentin
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机译：Immunofluorescent study of heterogeneity in smooth muscle cells of human fetal vessels using antibodies to myosin, desmin, and vimentin
Immunofluorescence-microscopy was applied to study the distribution of desmin, vimentin, and smooth muscle myosin in smooth muscle of human fetal vessels. Serial cryostat sections of the vessels examined all reacted positively with myosin and vimentin antibodies. However, heterogeneous staining of the vessels with desmin antibodies was observed. Thus, 2 types of smooth muscle staining were documented-desmin-negative and desmin-positive. Elastic and muscular arteries of the fetus (aorta, femoral and branchial artery) were desmin-negative while femoral and branchial veins were desmin-positive. In umbilical cord arteries and veins, the distribution of desmin-positive cells was largely localized to the outer layer of media, but not to the inner layer. In placenta, both desmin-positive and desmin-negative vessels were also revealed. Thus, differences in desmin expression by human vascular smooth muscle cells already exists during early stages of ontogeny.
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