Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression.

Thomson EM; Kumarathasan P; Calderon-Garciduenas LVincent R

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Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression.

机译：Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression.

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Recent work suggests that air pollution is a risk factor for cerebrovascular and neurodegenerative disease. Effects of inhaled pollutants on the production of vasoactive factors such as endothelin (ET) and nitric oxide (NO) in the brain may be relevant to disease pathogenesis. Inhaled pollutants increase circulating levels of ET-1 and ET-3, and the pituitary is a potential source of plasma ET, but the effects of pollutants on the expression of ET and NO synthase genes in the brain and pituitary are not known. In the present study, Fischer-344 rats were exposed by nose-only inhalation to particles (0, 5, 50mg/m3 EHC-93), ozone (0, 0.4, 0.8 ppm), or combinations of particles and ozone for 4 h. Real-time reverse transcription polymerase chain reaction was used to measure mRNA levels in the cerebral hemisphere and pituitary 0 and 24 h post-exposure. Ozone inhalation significantly increased preproET-1 but decreased preproET-3 mRNAs in the cerebral hemisphere, while increasing mRNA levels of preproET-1, preproET-3, and the ET-converting enzyme (ECE)-1 in the pituitary. Inducible NO synthase (iNOS) was initially decreased in the cerebral hemisphere after ozone inhalation, but increased 24 h post-exposure. Particles decreased tumour necrosis factor (TNF)-alpha mRNA in the cerebral hemisphere, and both particles and ozone decreased TNF-alpha mRNA in the pituitary. Our results show that ozone and particulate matter rapidly modulate the expression of genes involved in key vasoregulatory pathways in the brain and pituitary, substantiating the notion that inhaled pollutants induce cerebrovascular effects.

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《Environmental Research. Section A》 |2007年第2期|224-233|共10页
作者
Thomson EM; Kumarathasan P; Calderon-Garciduenas LVincent R;
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Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ont., Canada K1A 0K9.;

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原文格式 PDF
正文语种英语
中图分类环境卫生、环境医学;
关键词
Ozone; Brain; RNA; Messenger; Cerebral hemisphere; NOS; 臭氧; 脑; 信使;

Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression.

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