AbstractFormation of polyelectrolyte complexes (PECs) between cellulose derivatives in aqueous solution and their blood compatibility were examined. To this end, two types of quaternary ammonium cellulose derivatives, Q‐Cell and Q‐HEC, were prepared by treating cellulose and hydroxyethyl cellulose (HEC), respectively, with glycidyl trimethylammonium chloride. Anionic derivatives were carboxymethyl cellulose (CMC) with different degrees of substitution (DS) and cellulose sulfate (CS).In vivoblood tests were made by a method of peripheral vein indwelling suture. The results showed that the complex formation of Q‐Cell did not follow a stoichiometric reaction, but Q‐HEC reacted stoichiometrically with CMC and CS. It was also found that water‐insoluble cellulosic PECs are soluble in formic acid, showing that the cellulosic PEC films can be prepared from formic acid solutions. The blood tests revealed that by the criteria of the test method employed in this work, cellulosic PECs had a good blood comp
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