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>A novel nuclear protein which binds to Gγ and Aγ globin promoters and modulates hemoglobin synthesis in K562cells
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A novel nuclear protein which binds to Gγ and Aγ globin promoters and modulates hemoglobin synthesis in K562cells
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机译：A novel nuclear protein which binds to Gγ and Aγ globin promoters and modulates hemoglobin synthesis in K562cells
AbstractNuclear extract of human erythroleukemic cell line K562contains a 70 kDa protein which is gradually reduced when cells are induced to express globin genes by 25 μM hemin. When globin synthesis was inhibited by cycloheximide (100 μg/ml) or Actinomycin D (1 μg/ml), the disappearance of this protein was prevented. The 70 kDa nuclear protein exhibited strong binding to Gγ and Aγ globin promoters but not to β‐globin promoter. This suggests that this 70 kDa nuclear protein may be involved in the regulation of fetal globin gene exp
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