Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites.

Otake T; Yoshinaga J; Enomoto TMatsuda MWakimoto TIkegami MSuzuki ENaruse HYamanaka TShibuya NYasumizu TKato N

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Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites.

机译：Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites.

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摘要

The associations between in utero exposure to polychlorinated biphenyls (PCBs) or hydroxylated PCB metabolites (OH-PCBs), and free thyroxin (fT4) or thyroid-stimulating hormone (TSH) status in the newborn were investigated as a pilot study of a large-scale epidemiologic study on in utero PCB or OH-PCB exposure and thyroid function of the newborns. Umbilical cord tissue was used as the media for the biological monitoring of PCBs/OH-PCBs exposure in utero. For the measurement of fT4 and TSH, a heel-prick blood sample spotted on filter paper, which is called Guthrie card, is collected from each neonate at day 4-6 postpartum for this study when the mass screening sampling was performed. We showed that the concentration of total OH-PCBs and one of the OH-PCB congeners (OH-PCB 187) was related significantly to higher fT4 level of newborns. On the other hand, the concentration of total PCBs and PCB congeners (PCB 118, 138, 153, and 180) showed no relationship with fT4 and TSH level of the newborns. The results obtained in this pilot study indicated the possibility that in utero OH-PCBs exposure affects thyroid hormone status of newborns.

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来源
《Environmental Research. Section A》 |2007年第2期|240-246|共7页
作者
Otake T; Yoshinaga J; Enomoto TMatsuda MWakimoto TIkegami MSuzuki ENaruse HYamanaka TShibuya NYasumizu TKato N;
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作者单位

Department of Environmental Studies, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8563, Japan.;

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正文语种英语
中图分类环境卫生、环境医学;
关键词
Polychlorinated Biphenyls; Hydroxide Ion; Thyroid stimulating hormone measurement; 多氯联苯化合物; 甲状腺激素类;

Thyroid hormone status of newborns in relation to in utero exposure to PCBs and hydroxylated PCB metabolites.

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