Childhood acute myeloid leukaemia

RubnitzJ.E.; InabaH.

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Childhood acute myeloid leukaemia

机译：儿童急性髓性白血病

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Although acute myeloid leukaemia (AML) has long been recognized for its morphological and cytogenetic heterogeneity, recent high-resolution genomic profiling has demonstrated a complexity even greater than previously imagined. This complexity can be seen in the number and diversity of genetic alterations, epigenetic modifications, and characteristics of the leukaemic stem cells. The broad range of abnormalities across different AML subtypes suggests that improvements in clinical outcome will require the development of targeted therapies for each subtype of disease and the design of novel clinical trials to test these strategies. It is highly unlikely that further gains in long-term survival rates will be possible by mere intensification of conventional chemotherapy. In this review, we summarize recent studies that provide new insight into the genetics and biology of AML, discuss risk stratification and therapy for this disease, and profile some of the therapeutic agents currently under investigation.

机译：尽管长期以来，急性髓细胞白血病（AML）因其形态学和细胞遗传学异质性而得到认可，但最近的高分辨率基因组分析已证明其复杂性甚至超过了以前的想象。这种复杂性可以从白血病干细胞的遗传改变，表观遗传修饰和特征的数量和多样性中看出。跨不同AML亚型的广泛异常表明，临床结果的改善将需要针对每种疾病亚型开发靶向治疗，并需要设计新颖的临床试验来测试这些策略。仅通过加强常规化学疗法就不可能进一步提高长期生存率。在这篇综述中，我们总结了最近的研究，这些研究为AML的遗传学和生物学提供了新的见解，讨论了该疾病的风险分层和治疗方法，并对目前正在研究的某些治疗药物进行了概述。

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《British Journal of Haematology》 |2012年第3期|共18页
作者
RubnitzJ.E.; InabaH.;
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正文语种 eng
中图分类血液及淋巴系疾病;
关键词
Acute myeloid leukaemia; AML; Childhood leukaemia;

机译：急性髓性白血病;AML;儿童白血病;

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1. Increased activity of histone deacetylases in childhood acute lymphoblastic leukaemia and acute myeloid leukaemia: Support for histone deacetylase inhibitors as antileukaemic agents [J] . SonnemannJ., GruhnB., WittigS., British Journal of Haematology . 2012,第5期

机译：儿童急性淋巴细胞白血病和急性髓细胞性白血病中组蛋白脱乙酰酶的活性增加：支持组蛋白脱乙酰酶抑制剂作为抗白血病药
2. Prospective study of a therapeutic regimen with all-trans retinoic acid and anthracyclines in combination of cytarabine in children with acute promyelocytic leukaemia: The Japanese childhood acute myeloid leukaemia cooperative study [J] . Imaizumi M., Tawa A., Hanada R., British Journal of Haematology . 2010,第1期

机译：全反式维甲酸和蒽环类药物联合阿糖胞苷治疗儿童急性早幼粒细胞白血病的前瞻性研究：日本儿童急性髓样白血病合作研究
3. Prospective study of a therapeutic regimen with all-trans retinoic acid and anthracyclines in combination of cytarabine in children with acute promyelocytic leukaemia: The Japanese childhood acute myeloid leukaemia cooperative study [J] . Imaizumi M., Tawa A., Hanada R., British Journal of Haematology . 2010,第1期

机译：对急性早产儿白血病儿童组合中的所有反式视黄酸和蒽环类药物治疗方案的前瞻性研究：日本儿童急性髓性白血病合作研究
4. WGAN Latent Space Embeddings for Blast Identification in Childhood Acute Myeloid Leukaemia [C] . Roxane Licandro, Thomas Schlegl, Michael Reiter, International Conference on Pattern Recognition . 2018

机译：WGAN潜在空间嵌入在儿童急性髓性白血病中的爆炸鉴定。
5. Loss of Egr1 plays a role in murine leukemogenesis and may play a role in the development of acute myeloid leukemia and therapy-related acute myeloid leukemia. [D] . Joslin, John M. 2006

机译：Egr1的丢失在小鼠白血病的发生中起作用，并且可能在急性髓细胞性白血病和与治疗有关的急性髓细胞性白血病的发展中起作用。
6. Development of CNS leukaemia in acute myeloid leukaemia in childhood. [O] . H E Kay 1976

机译：儿童急性髓细胞性白血病中枢神经系统白血病的发展。
7. Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia working party. [O] . Chessells, JM, Harrison, CJ, Kempski, H, 2002

机译：婴儿急性淋巴细胞白血病和髓样白血病的临床特征，细胞遗传学和预后：MRC童年白血病工作组的报告。
8. Acute Lymphocytic Leukaemia in Children in the Netherlands. Results of Treatment According to Protocol ALL II (Dutch Childhood Leukaemia Study Group) and Immunological Studies after Cessation of Therapy [R] . Does-van den Berg, A. 1980

机译：荷兰儿童急性淋巴细胞白血病。根据方案aLL II（荷兰儿童白血病研究组）和停止治疗后的免疫学研究的治疗结果

Childhood acute myeloid leukaemia

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