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首页> 外文期刊>cell and tissue research >Expression of neurotrophin receptor trkB in rat cochlear hair cells at time of rearrangement of innervation
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Expression of neurotrophin receptor trkB in rat cochlear hair cells at time of rearrangement of innervation

机译：Expression of neurotrophin receptor trkB in rat cochlear hair cells at time of rearrangement of innervation

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The spatio-temporal distribution of the high-affinity neurotrophin receptor trkB was monitored during postnatal development of the rat cochlea. In addition to expression in presumptive afferent type I collaterals, afferent type II fibers, and efferent fibers, trkB immunoreactivity also transiently appeared in the sensory hair cells themselves, from postnatal days 5–9 in the basal turn, and from postnatal days 9–13 in the apical turn. A comparison of trkB with p75NGFR, which is expressed in afferent and efferent fibers, and GAP-43 and synaptophysin, which are expressed in efferent fibers, revealed a time/space correlation of trkB receptor expression in hair cells with the rearrangement of their innervation. Co-expression of the neurotrophin receptor and its ligand has been proposed to be functionally involved in regulating the survival of neurons independent of target-derived neurotrophin factor. Thus, the presence of trkB in target hair cells, suggests that auto/paracrine mechanisms play a role during this critical period of rearrangement of neural connecti

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