The protective and therapeutic effects of zinc chloride and desferrioxamine on skin exposed to nitrogen mustard.

Karayilanoglu T; Gunhan O; Kenar LKurt B

首页> 外文期刊>Military Medicine: Official Journal of AMSUS, The Society of the Federal Health Agencies >The protective and therapeutic effects of zinc chloride and desferrioxamine on skin exposed to nitrogen mustard.

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The protective and therapeutic effects of zinc chloride and desferrioxamine on skin exposed to nitrogen mustard.

机译：The protective and therapeutic effects of zinc chloride and desferrioxamine on skin exposed to nitrogen mustard.

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The nitrogen mustard (HN2), which contains chloroethyl groups, is a potent inhibitor of DNA synthesis and cell growth. It also has vesicant properties. Due to these damaging effects of HN2 on the skin, zinc chloride (ZnCl2) and desferrioxamine were used in the form of ointment for treatment and prevention of the histopathological destruction of skin of guinea pigs. According to results of the histopathological study, both ZnCl2 and desferrioxamine had therapeutic and protective effects for HN2-induced skin damage at moderate levels. Taking into consideration the alkylating effect of HN2 on the skin, our results suggest that ZnCl2 and desferrioxamine may be used in the prevention of nuclear damage and for handling the burns caused by the HN2.

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来源
《Military Medicine: Official Journal of AMSUS, The Society of the Federal Health Agencies》 |2003年第8期|614-617|共4页
作者
Karayilanoglu T; Gunhan O; Kenar LKurt B;
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作者单位

Department of NBC Defense, Gulhane Military Medical Academy, 06018 Ankara, Turkey.;

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原文格式 PDF
正文语种英语
中图分类特种医学;
关键词
Integumentary system; imidazole mustard; Deferoxamine; Therapeutic; protect; 去铁胺;

The protective and therapeutic effects of zinc chloride and desferrioxamine on skin exposed to nitrogen mustard.

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