AbstractA trihaloimidazole derivative (S‐377; 1‐(4‐chlorobutoxymethyl)‐2,4,5‐trichloroimidazole) caused giant excitatory junctional potentials by a single electrical stimulus to the excitatory nerves. Repetitive discharges were simultaneously induced in the nerve fibres. S‐377 also caused repetitive firing in the inhibitory nerve fibres. Permethrin showed quite similar actions on both the junction and nerve fibres. It was supposed that S‐377 inhibited the inactivating system of the sodium channel, like pyrethroids. However, S‐377 reduced the number of spikes of the permethrin‐induced repetitive discharges on the excitatory nerve fibres. These observations suggest that binding sites of S‐377 on sodium channels are different from t
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