AbstractCellular electrophoretic mobility, and therefore, surface charge/ unit area, was found to be constant throughout the cell cycle of synchronized L5178‐Y mouse lymphoblasts, remaining at – 1.21 μ sec−1V−1cm. Measured cell volumes of these synchronized cells increased linearly over the cell cycle and at mitosis each cell divided into two cells, each cell having half of the parent volume. An hypothesis is presented which explains the presence of a mobility peak at mitosis in cells which normally are grown attaching to a glass surface on the basis of differential morphological changes during mitosis; cells such as the L5178‐Ys, which do not attach to glass normally, do not undergo such morphological changes at mitosis and, therefore, would not demonstrate a mobility peak at
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