SummaryA specific IgE‐mediated response was evaluated in twenty‐eight workers exposed to TDI or MDI, with diagnosis of occupational asthma and positive to bronchial provocative challenge. The presence of anti‐diisocyanate IgE was observed in 27 of subjects exposed to TDI and 83 of those exposed to MDI, particularly in individuals who experienced an acute massive exposure. An immediate‐type response to bronchial provocative test was found in 66 of individuals with specific antibodies. Specific IgE are prevalent (91) in subjects who developed symptoms before 6 years of exposure to isocyanates. The results suggest an association between the presence of specific IgE, early asthmatic symptoms and heavy episodic e
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