Histopathological pattern of the liver and kidney of Rattus novergicuson prophylactic consumption of Acalypha godseffiana crude ethnolic extract

Odigie B.E.; Achukwu P.U.

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Histopathological pattern of the liver and kidney of Rattus novergicuson prophylactic consumption of Acalypha godseffiana crude ethnolic extract

机译：Histopathological pattern of the liver and kidney of Rattus novergicuson prophylactic consumption of Acalypha godseffiana crude ethnolic extract

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© CMS UNIBEN JMBR.Health concerns over prophylactic abuse of herbal drugs are worrisome. However, histopatlwlogical perspectives are not so common. This study was designed to examine the histopathological pattern of the liver and kidney of white rats exposed to prophylactic abuse ofAcalypha godseffiana crude leaf extract. Thirty (30) albino rats of both sexes, with average mean weight of 199.82g were randomly selected Into cages (A, B, C D) and a control cage (E) where n=6. Cages A -D received 200,400, 600, and 800 mg/kg body weight of extract respectively. Commercially purchased drinking water and standard top feed® were given ad libitum, for 30 days. The animals were weighed before and after extract administration. Dullness and restlessness were observed and was marked on the high dose treated animals. The animals were sacrificed on day 31 by cervical dislocation. Grossing was done and was fixed in 1096 buffered neutral formalin. Processed tissues at (3-5mm) were sectioned at 3- 5microns. Grossly, all organs slwwed no apparent changes while histological findings were normal. This study revealed that prophylactic consumption of A. godsefflana leaf extract does not result in any histological changes in the organs (Liver and Kidney) studied. It can therefore be recommAnded for use.

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《journal of medicine and biomedical research》 |2014年第1期|98-109|共页
作者
Odigie B.E.; Achukwu P.U.;
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Department of Medical Laboratory Science, School of Basic Medical Science, College of Medical Sciences, University of Benin;

Department of Medical Laboratory Science, College of Medicine, University of Nigeria;

Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Science, University of Benin;

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Haematoxylin and Eosin; Histological techniques; Prophylactic;

Histopathological pattern of the liver and kidney of Rattus novergicuson prophylactic consumption of Acalypha godseffiana crude ethnolic extract

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