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外文期刊>Arthritis and Rheumatism
>Quantitation of IgM‐ and IgG‐secreting B cells in the peripheral blood of patients with systemic lupus erythematosus
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Quantitation of IgM‐ and IgG‐secreting B cells in the peripheral blood of patients with systemic lupus erythematosus
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机译：Quantitation of IgM‐ and IgG‐secreting B cells in the peripheral blood of patients with systemic lupus erythematosus
AbstractAn enzyme‐linked immunospot assay was used to quantitate the number of autoantibody‐secreting B cells in the peripheral blood of 67 patients with systemic lupus erythematosus. These patients had 1.5–4‐fold more lymphocytes secreting IgG and IgM per million peripheral blood lymphocytes than did normal controls. There was a concomitant increase in the number of B cells secreting antibodies reactive with a diverse panel of foreign and self antigens (including actin, myosin, trinitrophenylated keyhole limpet hemocyanin, ovalbumin, and retroviral gp160). By comparison, the number of B cells producing anti‐DNA antibodies was increased disproportionately. The magnitude of this anti‐DNA response correlated significantly with disease activity. Thus, B cell activation in human systemic lupus erythematosus had characteristics of both generalized (polyclonal) B cell activation and (auto)antigen‐specific immun
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