Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats.

Baik SK; Kim YW; Kim HJLee JWCho BMKim DHChoi SHLee SH Chang KH

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Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats.

机译：Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats.

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BACKGROUND: In experimental studies, embolization of the cerebral hemisphere with triolein emulsion has revealed reversible magnetic resonance imaging (MRI) findings in the subacute stage. PURPOSE: To investigate the changes in the major metabolites, by proton magnetic resonance spectroscopy (MRS), in a cerebral fat embolism induced by a triolein emulsion. MATERIAL AND METHODS: The internal carotid arteries of 19 cats were injected with a triolein emulsion, and multivoxel MRS was performed 30 min, 1 day, and 7 days later. In the control group, six cats were injected with normal saline. The MR spectra were evaluated for N-acetyl aspartate (NAA), creatine (Cr), and choline (Cho), along with the presence of lipid and lactate. Semiquantitative analyses of NAA/Cr, Cho/Cr, NAA/Cho, and lipid/Cr ratios compared the median values of the ipsilateral metabolite ratios with those of the contralateral side and in the control group for each point in time. RESULTS: The NAA/Cr, Cho/Cr, and NAA/Cho ratios in the ipsilateral cerebral hemisphere of the embolized group after 30 min, 1 day, and 7days were not significantly different from the contralateral hemisphere of the embolized and control groups (P>0.05). The lipid/Cr ratio in the ipsilateral cerebral hemisphere of the embolized group was significantly higher when compared with the control group (P=0.012 at 30 min, P=0.001 on day 1, and P=0.018 on day 7). CONCLUSION: Cerebral fat embolism induced by a triolein emulsion resulted in no significant change in the major metabolites of the brain in the acute stage, except for an elevated lipid/Cr ratio, which suggests the absence of any significant hypoxic-ischemic changes in the lesions embolized using a fat emulsion.

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《Acta Radiologica》 |2008年第10期|1174-1181|共8页
作者
Baik SK; Kim YW; Kim HJLee JWCho BMKim DHChoi SHLee SH Chang KH;
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作者单位

Department of Radiology, College of Medicine and Medical Research Institute, Pusan National University, Pusan, South Korea.;

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正文语种英语
中图分类放射医学;
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Animals; Aspartic Acid; Brain; Cats; Choline; Contrast Media; Creatine; Disease Models; Animal; Disease Progression; Embolism; Fat; Follow-Up Studies; Gadolinium DTPA; Image Enhancement; Intracranial Embolism; Lactic Acid; Lipid Metabolism; Lipids; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Sodium Chloride; Triolein; *动物; 天冬氨酸; 脑; 猫; 胆碱; 造影剂; 肌酸; 疾病模型; 动物; 疾病恶化; 栓塞; 脂肪; 随访研究; 钆DTPA; 图像增强; 乳酸; 脂类; 磁共振成像; 氯化钠; 三油酸脂;

Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats.

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