Impact of hydroxyurea therapy on serum fatty acids of beta-thalassemia patients

Iqbal Ayesha; Siddiqui Amna Jabbar; Huang Jian-HuaAnsari Saqib HussainMusharraf Syed Ghulam

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Impact of hydroxyurea therapy on serum fatty acids of beta-thalassemia patients

机译：Impact of hydroxyurea therapy on serum fatty acids of beta-thalassemia patients

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Introduction and objective Fatty acids (FAs) influence cell and tissue metabolism, function, responsiveness to hormonal and other signals in addition to maintenance of membrane integrity of cells. beta-Thalassemia is a prevalent inherited blood disorder characterized by abnormal red cell membrane structure and function. Induction of HbF by hydroxyurea (HU) is an enduring therapeutic intervention to manage this. Therefore, in the present study we have carried out the quantification of thirteen free fatty acids to disclose the prognosis of HU in beta-thalassemia.

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来源
《Metabolomics :》 |2018年第3期|Article 27-Article 27|共11页
作者
Iqbal Ayesha; Siddiqui Amna Jabbar; Huang Jian-HuaAnsari Saqib HussainMusharraf Syed Ghulam;
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作者单位

Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan;

TCM, Changsha, Hunan, Peoples R China;

Natl Inst Blood Dis & Bone Marrow Transplantat, Karachi, Pakistan;

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原文格式 PDF
正文语种英语
中图分类生理学;
关键词
beta-Thalassemia; Fatty acids; GC-MRM-MS; Hydroxyurea;

Impact of hydroxyurea therapy on serum fatty acids of beta-thalassemia patients

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