AbstractThein vitroandin vivoeffects of selected pharmacologic agents on cytosolic aldehyde dehydrogenase in the adult rat testicles were studied. Naltrexone, a narcotic antagonist, significantly inhibited epididymal but not testicular aldehyde dehydrogenasein vitro.Greaterin vitroinhibition of aldehyde dehydrogenase in the epididymal preparation was determined in the presence of diphenyhydramine, a histamine H1‐receptor antagonist and by amantadine hydrochloride, an antiviral/antiparkinsonian agent. The latter drug also inhibited testicular aldehyde dehydrogenase from corresponding controls. Thein vitroinhibition was non‐competitive as evaluated by reciprocal plots of the velocity of the reaction as a function of substrate concentrations. Short‐term oral administration of a biologically active metabolite of flutamide, a nonsteroidal antiandrogen, significantly induced testicular aldehyde dehydrogenase without concomitant changes in epididymal aldehyde dehydrogenase from respective controls. Conversely, administration of ethinylestradiol, an estrogenic steroid, inhibited testicular but not epididymal aldehyde hydrogenase in th
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