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外文期刊>international journal of immunogenetics
>ROLE OF CELL‐CELL INTERACTIONS IN MITOGENIC STIMULATION OF LYMPHOCYTES: I. DISSOCIATION OF CONCANAVALIN A‐INDUCIBLE LYMPHOCYTE ACTIVATION AND AGGLUTINATION
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ROLE OF CELL‐CELL INTERACTIONS IN MITOGENIC STIMULATION OF LYMPHOCYTES: I. DISSOCIATION OF CONCANAVALIN A‐INDUCIBLE LYMPHOCYTE ACTIVATION AND AGGLUTINATION
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机译：ROLE OF CELL‐CELL INTERACTIONS IN MITOGENIC STIMULATION OF LYMPHOCYTES: I. DISSOCIATION OF CONCANAVALIN A‐INDUCIBLE LYMPHOCYTE ACTIVATION AND AGGLUTINATION
SUMMARYThe aim of the study was to decide whether the delayed agglutination of lymphocytes following mitogenic doses of concanavalin A (Con A) is a prerequisite of the activation process. It was shown that both phenomena can be greatly dissociated; suitable doses of cytochalasin B (CB) completely block agglutination, while the capacity to respond (by 14Cthymidine incorporation) to Con A‐induced stimulation is retained. It was concluded that agglutinability is acquired in the early phase of the activation process, concomitant with induced changes in the cell membrane structure; the manifestation (i.e. agglutination) of this capacity is not necessary for the activation of the cell nucleus to take place, and it depends on the cells' chances of being brought together, either by active movement or by external force
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