...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>the american journal of dermatopathology >Immunohistologic Findings and Adhesion Molecule Pattern in Primary Pure Cutaneous Rosai-Dorfman Disease With Xanthomatous Features
【24h】

Immunohistologic Findings and Adhesion Molecule Pattern in Primary Pure Cutaneous Rosai-Dorfman Disease With Xanthomatous Features

机译：Immunohistologic Findings and Adhesion Molecule Pattern in Primary Pure Cutaneous Rosai-Dorfman Disease With Xanthomatous Features

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Skin involvement is common in sinus histiocytosis with massive lymphadenopathy (SH, Rosai-Dorfman disease), but pure cutaneous cases are rare. A 70-year-old woman presented with a 10-year history of large red-orange nodules and plaques on her upper arms, face, and buttocks, without evidence of lymphadenopathy or internal involvement. Distinctive histopathologic differences were observed according to the duration of the lesions. In recent lesions, the dermal infiltrate was mostly composed of sheets of characteristic SH cells; on the other hand, in long-lasting lesions, the presence of xanthomatous changes and prominent fibrosis, in keeping with the self-limited nature of this disease, raises problems of differential diagnosis with other xanthohistiocytic disorders. Immunophenotypic studies showed that the SH cells are S-100+ CD1a negative-activated macrophages, capable of lysosomal activity. The adhesion molecule pattern of SH cells (CD11b+, CD11C+, CD18+, CD62L+, and CD103+) was similar to that of circulating monocytes, suggesting their recent migration from the bloodstream.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号