The pharmacokinetics of centchroman (ormeloxifene), a nonsteroidal antifertility agent, was determined in 4 nursing mothers in the postpartum period after a single 30mg oral dose of the drug. The concentration-time profile of centchroman in serum and milk were not parallel. The milksol;serum (Msol;S) area under the curve ratio of centchroman was 1.47 plusmn; 0.56. Individual mean Msol;S concentration ratios of centchroman showed significant interindividual variation (range 0.38 to 1.94). A comparison of pharmacokinetic parameters in the nursing women with those reported previously in nonlactating women showed an insignificant difference; time to maximum concentration occurred later in milk than in maternal serum. The average infant dose of centchroman via breast milk, assuming a weekly milk intake of 1.05 Lsol;kg and 100percnt; absorption, would be 7.43 plusmn; 3.18percnt; per week of the maternal dose.
展开▼
