AbstractOsteoarthrosis of the rat knee joint was induced successfully by intra‐articular injection of 2 hydrogen peroxide (H2O2) and running load. In the group receiving two injections of physiological saline with running load, no histological osteoarthrotic knees were developed up to 8 weeks after the injection. In the group receiving two 2 H2O2injections and running load, advanced osteoarthrosis occurred in all knees 8 weeks after the first injection, and the Mankin's score of osteoarthrotic knees appeared to be higher than the group receiving two 2 H2O2injections without running load (p<0.004, Kruskal‐WallisHtest). In the rats receiving a single 2 H2O2injection with running load and a vitamin E‐enriched diet, the inhibitory effect of vitamin E on the development of osteoarthrosis was statistically significant compared to the regular diet group (p<0.05, Wilcoxon rank
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