Evolutionary Comeuppance: Mitochondrial Stress Awakens the Remnants of Ancient Bacterial Warfare

Frankino Phillip A.; Phillip A. Frankino; Moehle Erica A.Erica A. MoehleDillin AndrewAndrew Dillin

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Evolutionary Comeuppance: Mitochondrial Stress Awakens the Remnants of Ancient Bacterial Warfare

机译：Evolutionary Comeuppance: Mitochondrial Stress Awakens the Remnants of Ancient Bacterial Warfare

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Mitochondria are organelles descended from an endosymbiosed bacterium, and many bacterial toxins impair mitochondria, likely as an echo of ancient bacterial warfare. However, the signal transduction pathways that translate mitochondrial dysfunction into a transcriptional program for detoxification have not been well understood. In this issue of Cell Metabolism, Mao et al. (2019) provide insight into how mitochondrial perturbations can activate both the mitochondrial unfolded protein response (UPRmlto) and detoxification response and, importantly, how these responses differentially affect organismal physiology under normal conditions or with pathogenic challenges.

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《Cell metabolism》 |2019年第5期|1015-1017|共3页
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Frankino Phillip A.; Phillip A. Frankino; Moehle Erica A.Erica A. MoehleDillin AndrewAndrew Dillin;
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Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of;

Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA;

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正文语种英语
中图分类内分泌腺疾病及代谢病;
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Evolutionary Comeuppance: Mitochondrial Stress Awakens the Remnants of Ancient Bacterial Warfare

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