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Internal fixator for use in the mouse

机译:用于鼠标的内部固定器

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摘要

Knockout techniques enable us to expand our knowledge about bonerepair processes. Since they require the use of mice, such studies necessitate the development of special technologies. Mechano-biological reactions play a determining role in fracture healing, and therefore controlled conditions of stability are essential. Achieving fixation with a low-mass implant avoids uncontrolled inertial loading and enables free ambulation. Aminiaturised version of conventional internal fixation as used in humans has been developed. The method consists of a plate-like internal fixator with locked screws. It permits compression fixation or splinting fixation at selectable levels of flexibility. A guide is used for standardised application of the fixator, the screws and the osteotomy. Locking the screws to the plate enables elevation of the fixator from the bone surface; therefore, minimal contact damage to the periosteal blood supply can be expected. The technology is now in use in several laboratories.
机译:剔除技术使我们能够扩展有关骨修复过程的知识。由于它们需要使用小鼠,因此此类研究有必要开发特殊技术。机械生物学反应在骨折愈合中起决定性作用,因此受控的稳定性条件至关重要。使用低质量植入物实现固定可避免不受控制的惯性载荷,并实现自由移动。已经开发出用于人类的常规内部固定的小型化版本。该方法由带锁紧螺钉的板状内部固定器组成。它允许在可选的灵活性级别上进行压缩固定或夹板固定。指南用于固定器,螺钉和截骨术的标准化应用。将螺钉锁在板上可以使固定器从骨表面抬起。因此,可以预期对骨膜血液供应的最小接触损伤。现在,该技术已在多个实验室中使用。

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