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外文期刊>european journal of neuroscience
>Blockade of A2aAdenosine Receptors Positively Modulates Turning Behaviour and c‐Fos Expression Induced by D1Agonists in Dopamine‐denervated Rats
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Blockade of A2aAdenosine Receptors Positively Modulates Turning Behaviour and c‐Fos Expression Induced by D1Agonists in Dopamine‐denervated Rats
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机译：Blockade of A2aAdenosine Receptors Positively Modulates Turning Behaviour and c‐Fos Expression Induced by D1Agonists in Dopamine‐denervated Rats
AbstractIn rats with unilateral 6‐hydroxydopamine lesions of the dopaminergic nigrostriatal pathway, administration of the A2aadenosine antagonist SCH 58261 alone did not induce any motor asymmetry but strongly potentiated the contralateral turning behaviour induced by the dopamine D1agonist SKF 38393. SCH 58261 also increased the number of Fos‐like positive nuclei induced by SKF 38393 in the 6‐hydroxydopamine‐lesioned striatum. Intense potentiation of D1‐dependent turning behaviour and c‐Fos expression was also observed after administration of the A2a/A1antagonist CGS 15943. Administration of the A1adenosine receptor antagonist DPCPX induced a small potentiation of D1‐mediated contralateral turning while c‐Fos expression induced by SKF 38393 was not modified. The results suggest that endogenous adenosine acting on A2areceptors can exert an inhibitory influence on the functional expression of D1‐mediated responses in dopamine‐denervated rats, and propose new possible therapeutic approaches in the treatment of
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