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In this issue.

机译：在这个问题上。

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摘要

This issue begins with 2 short contributions from readers. The issue starts with a commentary on the use of chemoprotectants-agents that can protect normal cells from damage because of chemotherapy drugs. The authors, headed by Gopabandhu Jena of the National Institute of Pharmaceutical Education and Research in India, specifically advocate the use of the new disciplines of toxicogenomics and metabolo-mics in research on new chemoprotectants. This perspective may contribute to rational drug design of chemoprotective as well as chemosensitizing agents and would be an intriguing addition to the strategy we commonly see discussed in Inte-grative Cancer Therapies of evaluating well-known natural products for chemoprotective activity. Amirhossein Sahebkar and Mehrdad Pranshahi have submitted a brief letter on the possible 5-lipoxygenase activity of prenylcoumarins, phyto-chemicals found in plants of the citrus and carrot families, and especially in citrus fruits. 5-Lipoxygenase is an important cancer prevention and possibly cancer treatment target, and their suggestion certainly deserves further consideration.
机译：本期从读者的两篇短文开始。首先从对化学保护剂的评论开始，化学保护剂可以保护正常细胞免受化疗药物的损害。由印度国家药物教育和研究所的Gopabandhu Jena领导的作者特别提倡在新化学保护剂的研究中使用毒理基因组学和代谢组学的新学科。这种观点可能有助于化学保护剂和化学增敏剂的合理药物设计，并且将成为我们通常在综合癌症疗法中评估著名的天然产物化学保护活性的策略中有趣的补充。 Amirhossein Sahebkar和Mehrdad Pranshahi提交了一封简短的信，内容涉及异戊二烯香豆素，在柑桔和胡萝卜家族的植物中，尤其是在柑桔类水果中发现的植物化学物质，可能具有的5-脂氧合酶活性。 5-脂氧合酶是重要的癌症预防和可能的癌症治疗靶标，其建议当然值得进一步考虑。

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