Several advances have been made in understanding the polymorphisms of the neutrophil Fchyphen;ggr;hyphen;receptor Illb lpar;Fcggr;RIIIbrpar;. In one recent study, 21 individuals whose neutrophils lack Fcggr;Rlllb were found to be missing the entireFcggr;RIIIBandFcggr;RIICgenes. Another polymorphism of Fcggr;Rlllb, SH, has been characterized. New methods to determine the genotype ofFcggr;RIIIBfor NA1, NA2, and SH using leukocyte genomic DNA have been described. A new monoclonal antibody to neutrophilhyphen;specific antigen NB1 was produced. Advances have been made in understanding alloimmunization in granulocyte transfusion recipients and the treatment of autoimmune neutropenia with granulocyte colonyhyphen;stimulating factor lpar;GCSFrpar;. Granulocyte transfusion recipients were found to be alloimmunized both to neutrophilhyphen;specific and HLA antigens, suggesting that the transfusion of these patients with granulocytes matched only for HLA antigens will not be effective. A case report suggests that the beneficial effects of Ghyphen;CSF on patients with autoimmune neutropenia is due in part to GCSF's action of increasing plasma levels of soluble Fcggr;Rlllb.
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